DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQQVPRGQNQR
Uniprot ID:
Q3SYA9
Source protein:
Putative POM121-like protein 1
Source gene:
POM121L1P
Class:
SCF_FBXL2
Location:
407:417
E3 ligase:
FBXL2
DEGRON score:
0.5978
ASA_SCORE:
98.1273
COIL:
0.8236
CONS_SCORE:
0
DSS_SCORE:
0.7548
HELIX:
0.1285
FCONS_SCORE:
0
RIG_SCORE:
0.6411
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121L1P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQQVPRGQNQR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q3SYA9
Putative POM121-like protein 1
SCF_FBXL2
407:417
LQQVPRGQNQR
FBXL2
0.5978
More...
