DegronMD

Uniprot ID: Q9Y2Y9

Source protein: Krueppel-like factor 13

Source gene: KLF13

Class: SCF_FBXL2

Location: 257:265

E3 ligase: FBXL2

DEGRON score: 0.6713

ASA_SCORE: 87.5333

COIL: 0.8221

CONS_SCORE: 0.4149

DSS_SCORE: 0.6629

HELIX: 0.0989

FCONS_SCORE: 0.9083

RIG_SCORE: 0.581

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R265W	ACH-001518	Endometrial/Uterine Cancer	CCLE	LQRRGGGSR	SCF_FBXL2	0.8634
p.R265Q	TCGA-WS-AB45	COAD	TCGA	LQRRGGGSR	SCF_FBXL2	0.7329
p.G262R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LQRRGGGSR	SCF_FBXL2	0.6457
p.G262R	ACH-000920	Leukemia	CCLE	LQRRGGGSR	SCF_FBXL2	0.6457
p.S264T	SIDM01335	Kidney Carcinoma	GDSC	LQRRGGGSR	SCF_FBXL2	0.6005
p.S264T	ACH-000513	Kidney Cancer	CCLE	LQRRGGGSR	SCF_FBXL2	0.6005
p.G255E	TCGA-EE-A29D	SKCM	TCGA	LQRRGGGSR	SCF_FBXL2	0.2778
p.P254T	TCGA-FS-A1ZP	SKCM	TCGA	LQRRGGGSR	SCF_FBXL2	0.25
p.A250T	SIDM00980	Gastric Carcinoma	GDSC	LQRRGGGSR	SCF_FBXL2	0.1389
p.A250T	ACH-000948	Gastric Cancer	CCLE	LQRRGGGSR	SCF_FBXL2	0.1389
p.A250T	ACH-001379	Pancreatic Cancer	CCLE	LQRRGGGSR	SCF_FBXL2	0.1389
p.A250T	23132-87	stomach	COSMIC	LQRRGGGSR	SCF_FBXL2	0.1389
p.R274C	TCGA-BR-8487	STAD	TCGA	LQRRGGGSR	SCF_FBXL2	0.0833
p.R274C	DO47867	STAD	ICGC	LQRRGGGSR	SCF_FBXL2	0.0833
p.R248S	TCGA-CV-7261	HNSC	TCGA	LQRRGGGSR	SCF_FBXL2	0.0833
p.R248S	DO15062	HNSC	ICGC	LQRRGGGSR	SCF_FBXL2	0.0833
p.R248S	DO35442	PACA	ICGC	LQRRGGGSR	SCF_FBXL2	0.0833
p.R274H	TCGA-DX-A1L0	SARC	TCGA	LQRRGGGSR	SCF_FBXL2	0.0833
p.R274L	SIDM02044	Colorectal Carcinoma	GDSC	LQRRGGGSR	SCF_FBXL2	0.0833
p.R248H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	LQRRGGGSR	SCF_FBXL2	0.0833
p.R248H	ACH-000795	Leukemia	CCLE	LQRRGGGSR	SCF_FBXL2	0.0833
p.R248H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	LQRRGGGSR	SCF_FBXL2	0.0833

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2Y9	Krueppel-like factor 13	SCF_FBXL2	257:265	LQRRGGGSR	FBXL2	0.6713	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons