DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LQRRGLDSR
Uniprot ID:
Q1KMD3
Source protein:
Heterogeneous nuclear ribonucleoprotein U-like protein 2
Source gene:
HNRNPUL2
Class:
SCF_FBXL2
Location:
15:23
E3 ligase:
FBXL2
DEGRON score:
0.6911
ASA_SCORE:
88.1667
COIL:
0.5952
CONS_SCORE:
0.4729
DSS_SCORE:
0.3022
HELIX:
0.3978
FCONS_SCORE:
1.0525
RIG_SCORE:
0.7303
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L6M
ACH-000844
Lung Cancer
CCLE
LQRRGLDSR
SCF_FBXL2
0.5278
Drug responses associated with HNRNPUL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQRRGLDSR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q1KMD3
Heterogeneous nuclear ribonucleoprotein U-like protein 2
SCF_FBXL2
15:23
LQRRGLDSR
FBXL2
0.6911
More...