DegronMD

Uniprot ID: Q0VF96

Source protein: Cingulin-like protein 1

Source gene: CGNL1

Class: SCF_FBXL2

Location: 366:371

E3 ligase: FBXL2

DEGRON score: 0.9403

ASA_SCORE: 101.5667

COIL: 0.7128

CONS_SCORE: 0.6976

DSS_SCORE: 0.6938

HELIX: 0.1968

FCONS_SCORE: 1.0951

RIG_SCORE: 0.672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R377I	TCGA-AN-A046	BRCA	TCGA	LQRRGR	SCF_FBXL2	0.1667
p.R377I	DO1285	BRCA	ICGC	LQRRGR	SCF_FBXL2	0.1667
p.Q367R	TCGA-D1-A2G0	UCEC	TCGA	LQRRGR	SCF_FBXL2	0.7329
p.Q367R	DO43049	UCEC	ICGC	LQRRGR	SCF_FBXL2	0.7329
p.R375Q	TCGA-EE-A183	SKCM	TCGA	LQRRGR	SCF_FBXL2	0.2222
p.R375Q	DO37715	SKCM	ICGC	LQRRGR	SCF_FBXL2	0.2222
p.I378S	TCGA-EI-6917	READ	TCGA	LQRRGR	SCF_FBXL2	0.1389
p.I378S	DO36881	READ	ICGC	LQRRGR	SCF_FBXL2	0.1389
p.K359T	TCGA-HC-A8CY	PRAD	TCGA	LQRRGR	SCF_FBXL2	0.25
p.K359T	DO219253	PRAD	ICGC	LQRRGR	SCF_FBXL2	0.25
p.T380P	DO229010	COCA	ICGC	LQRRGR	SCF_FBXL2	0.5278
p.T380P	DO229013	COCA	ICGC	LQRRGR	SCF_FBXL2	0.5278
p.T380P	DO229016	COCA	ICGC	LQRRGR	SCF_FBXL2	0.5278
p.T380P	DO229003	COCA	ICGC	LQRRGR	SCF_FBXL2	0.5278
p.T380P	DO229005	COCA	ICGC	LQRRGR	SCF_FBXL2	0.5278
p.I357T	DO228322	MALY	ICGC	LQRRGR	SCF_FBXL2	0.0833
p.I357T	SIDM01247	Burkitt's Lymphoma	GDSC	LQRRGR	SCF_FBXL2	0.0833
p.I357T	ACH-001636	Lymphoma	CCLE	LQRRGR	SCF_FBXL2	0.0833
p.I357T	ACH-002300	Lymphoma	CCLE	LQRRGR	SCF_FBXL2	0.0833
p.I357T	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	LQRRGR	SCF_FBXL2	0.0833
p.K374M	DO222532	MELA	ICGC	LQRRGR	SCF_FBXL2	0.3611
p.R369G	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	LQRRGR	SCF_FBXL2	0.6457
p.N376S	SIDM01140	Ovarian Carcinoma	GDSC	LQRRGR	SCF_FBXL2	0.1944
p.N376S	ACH-001374	Ovarian Cancer	CCLE	LQRRGR	SCF_FBXL2	0.1944
p.N376S	PA-1	ovary	COSMIC	LQRRGR	SCF_FBXL2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VF96	Cingulin-like protein 1	SCF_FBXL2	366:371	LQRRGR	FBXL2	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons