DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQTLRGPSR
Uniprot ID:
Q8NCQ5
Source protein:
F-box only protein 15
Source gene:
FBXO15
Class:
SCF_FBXL2
Location:
16:24
E3 ligase:
FBXL2
DEGRON score:
0.966
ASA_SCORE:
96.7667
COIL:
0.7923
CONS_SCORE:
0.2433
DSS_SCORE:
0.5039
HELIX:
0.1918
FCONS_SCORE:
1.0152
RIG_SCORE:
0.7147
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q17H
TCGA-XP-A8T8
ESCA
TCGA
LQTLRGPSR
SCF_FBXL2
0.7582
Drug responses associated with FBXO15 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQTLRGPSR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NCQ5
F-box only protein 15
SCF_FBXL2
16:24
LQTLRGPSR
FBXL2
0.966
More...