DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LQTPTST
Uniprot ID:
Q96DF8
Source protein:
Splicing factor ESS-2 homolog
Source gene:
ESS2
Class:
DEG_SCF_FBW7_1
Location:
435:441
E3 ligase:
FBXW7
DEGRON score:
0.9962
ASA_SCORE:
94.2857
COIL:
0.9459
CONS_SCORE:
0.4219
DSS_SCORE:
0.7667
HELIX:
0.009
FCONS_SCORE:
1.2987
RIG_SCORE:
0.5807
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ESS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQTPTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96DF8
Splicing factor ESS-2 homolog
DEG_SCF_FBW7_1
435:441
LQTPTST
FBXW7
0.9962
More...