DegronMD

Uniprot ID: Q6VMQ6

Source protein: Activating transcription factor 7-interacting protein 1

Source gene: ATF7IP

Class: DEG_SCF_FBW7_1

Location: 738:744

E3 ligase: FBXW7

DEGRON score: 0.7254

ASA_SCORE: 91.7286

COIL: 0.9066

CONS_SCORE: 0.5658

DSS_SCORE: 0.4608

HELIX: 0.021

FCONS_SCORE: 1.1155

RIG_SCORE: 0.7124

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S744L	TCGA-AJ-A3EL	UCEC	TCGA	LQTPVTS	DEG_SCF_FBW7_1	0.7667
p.K737R	TCGA-AX-A0J0	UCEC	TCGA	LQTPVTS	DEG_SCF_FBW7_1	0.3056
p.V732L	TCGA-C5-A7CK	CESC	TCGA	LQTPVTS	DEG_SCF_FBW7_1	0.1667
p.L747I	TCGA-EE-A181	SKCM	TCGA	LQTPVTS	DEG_SCF_FBW7_1	0.25
p.P754S	TCGA-EJ-A6RC	PRAD	TCGA	LQTPVTS	DEG_SCF_FBW7_1	0.0556
p.P728S	TCGA-ER-A3PL	SKCM	TCGA	LQTPVTS	DEG_SCF_FBW7_1	0.0556
p.P728H	TCGA-FP-A4BE	STAD	TCGA	LQTPVTS	DEG_SCF_FBW7_1	0.0556
p.S743L	DO221939	ALL	ICGC	LQTPVTS	DEG_SCF_FBW7_1	0.7667
p.S743L	DO41542	UCEC	ICGC	LQTPVTS	DEG_SCF_FBW7_1	0.7667
p.V731L	DO49000	CESC	ICGC	LQTPVTS	DEG_SCF_FBW7_1	0.1389
p.P753S	DO219249	PRAD	ICGC	LQTPVTS	DEG_SCF_FBW7_1	0.0833
p.L746I	DO37444	SKCM	ICGC	LQTPVTS	DEG_SCF_FBW7_1	0.2778
p.K736R	DO41133	UCEC	ICGC	LQTPVTS	DEG_SCF_FBW7_1	0.2778
p.S742N	SIDM00773	Non-Cancerous	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM01126	Small Cell Lung Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00656	Burkitt's Lymphoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00846	Cervical Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00210	Ovarian Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00878	Breast Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00971	Breast Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00254	Neuroblastoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00774	Breast Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00760	Small Cell Lung Carcinoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.S742N	SIDM00641	Burkitt's Lymphoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.7069
p.L733V	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPVTS	DEG_SCF_FBW7_1	0.1944
p.L733V	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPVTS	DEG_SCF_FBW7_1	0.1944
p.T748P	ACH-000916	Lung Cancer	CCLE	LQTPVTS	DEG_SCF_FBW7_1	0.2222
p.T748P	NCI-H1573	lung	COSMIC	LQTPVTS	DEG_SCF_FBW7_1	0.2222
p.S746C	ACH-001864	Bile Duct Cancer	CCLE	LQTPVTS	DEG_SCF_FBW7_1	0.2778
p.T747P	NCI-H1573	lung	COSMIC	LQTPVTS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQTPVTS

Degron related mutations and impact score

Drug responses associated with ATF7IP mutations

All proteins holding degron of LQTPVTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SCF_FBW7_1	738:744	LQTPVTS	FBXW7	0.7254	More...