DegronMD

Uniprot ID: P19429

Source protein: Troponin I, cardiac muscle

Source gene: TNNI3

Class: DEG_APCC_DBOX_1

Location: 169:177

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9946

ASA_SCORE: 90.5778

COIL: 0.41

CONS_SCORE: 0.7536

DSS_SCORE: 0.4288

HELIX: 0.5167

FCONS_SCORE: 1.5449

RIG_SCORE: 0.7665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D168E	TCGA-17-Z025	LUAD	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.3056
p.A163D	TCGA-99-7458	LUAD	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.1667
p.A163D	TCGA-B5-A0JY	UCEC	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.1667
p.R162Q	TCGA-AG-3592	READ	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.1389
p.R162Q	TCGA-C5-A2LY	CESC	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.1389
p.K174N	TCGA-B5-A0JY	UCEC	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.5806
p.E182D	TCGA-BS-A0UV	UCEC	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.1944
p.E182D	TCGA-IB-7651	PAAD	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.1944
p.E182D	TCGA-ND-A4WC	UCS	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.1944
p.R186W	TCGA-D1-A174	UCEC	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.0833
p.A171V	TCGA-D3-A8GI	SKCM	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.5825
p.T181P	TCGA-FB-AAPZ	PAAD	TCGA	LRAHLKQVK	DEG_APCC_DBOX_1	0.6667
p.E184K	DO2819	BRCA	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.1389
p.R167H	DO49095	COAD	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.2778
p.R167H	DO50306	ESAD	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.2778
p.R179H	DO230310	COCA	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.2778
p.E177D	DO230343	COCA	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.6758
p.E177D	DO42472	UCEC	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.6758
p.R179C	DO223029	ESCA	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.2778
p.I170T	DO23256	LINC	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.7078
p.K180R	DO27192	LUSC	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.25
p.G175E	DO222749	MELA	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.7199
p.R167C	DO46657	PAAD	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.2778
p.R167C	DO43971	UCEC	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.2778
p.K168N	DO46657	PAAD	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.3056
p.R161W	DO40900	UCEC	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.1111
p.K180N	DO52402	UCEC	ICGC	LRAHLKQVK	DEG_APCC_DBOX_1	0.25
p.K182R	NCI-H810	lung	COSMIC	LRAHLKQVK	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19429	Troponin I, cardiac muscle	DEG_APCC_DBOX_1	169:177	LRAHLKQVK	APC,CDC20,FZR1	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRAHLKQVK

Degron related mutations and impact score

Drug responses associated with TNNI3 mutations

All proteins holding degron of LRAHLKQVK