DegronMD

Uniprot ID: Q8N884

Source protein: Cyclic GMP-AMP synthase

Source gene: CGAS

Class: DEG_APCC_DBOX_1

Location: 165:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9132

ASA_SCORE: 70

COIL: 0.3009

CONS_SCORE: 0.5411

DSS_SCORE: 0.2324

HELIX: 0.69

FCONS_SCORE: 1.2429

RIG_SCORE: 0.8465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A167P	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAVLEKLK	DEG_APCC_DBOX_1	0.6392
p.A167P	SIDM01104	Melanoma	GDSC	LRAVLEKLK	DEG_APCC_DBOX_1	0.6392
p.A167P	SIDM00130	Pancreatic Carcinoma	GDSC	LRAVLEKLK	DEG_APCC_DBOX_1	0.6392
p.A167V	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAVLEKLK	DEG_APCC_DBOX_1	0.5825
p.A167V	SIDM01104	Melanoma	GDSC	LRAVLEKLK	DEG_APCC_DBOX_1	0.5825
p.A167V	SIDM00130	Pancreatic Carcinoma	GDSC	LRAVLEKLK	DEG_APCC_DBOX_1	0.5825
p.A167E	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	LRAVLEKLK	DEG_APCC_DBOX_1	0.659
p.A167E	LU-65	lung	COSMIC	LRAVLEKLK	DEG_APCC_DBOX_1	0.659

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N884	Cyclic GMP-AMP synthase	DEG_APCC_DBOX_1	165:173	LRAVLEKLK	APC,CDC20,FZR1	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons