DegronMD

Uniprot ID: O00459

Source protein: Phosphatidylinositol 3-kinase regulatory subunit beta

Source gene: PIK3R2

Class: DEG_SCF_FBW7_1

Location: 344:351

E3 ligase: FBXW7

DEGRON score: 0.9612

ASA_SCORE: 50.1375

COIL: 0.6926

CONS_SCORE: 0.6854

DSS_SCORE: 0.4375

HELIX: 0.2239

FCONS_SCORE: 1.1039

RIG_SCORE: 0.7558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R345W	TCGA-BR-6802	STAD	TCGA	LRDTPDGT	DEG_SCF_FBW7_1	0.7523
p.R345W	TCGA-DU-6392	LGG	TCGA	LRDTPDGT	DEG_SCF_FBW7_1	0.7523
p.R345W	DO22237	LGG	ICGC	LRDTPDGT	DEG_SCF_FBW7_1	0.7523
p.R345W	DO38332	STAD	ICGC	LRDTPDGT	DEG_SCF_FBW7_1	0.7523
p.R355P	TCGA-D3-A8GJ	SKCM	TCGA	LRDTPDGT	DEG_SCF_FBW7_1	0.2222
p.R355P	DO50285	SKCM	ICGC	LRDTPDGT	DEG_SCF_FBW7_1	0.2222
p.K343R	TCGA-FJ-A3ZE	BLCA	TCGA	LRDTPDGT	DEG_SCF_FBW7_1	0.75
p.K343R	DO484	BLCA	ICGC	LRDTPDGT	DEG_SCF_FBW7_1	0.75
p.S358Y	TCGA-FS-A1ZQ	SKCM	TCGA	LRDTPDGT	DEG_SCF_FBW7_1	0.1389
p.S358Y	DO37442	SKCM	ICGC	LRDTPDGT	DEG_SCF_FBW7_1	0.1389
p.R355L	DO228948	LICA	ICGC	LRDTPDGT	DEG_SCF_FBW7_1	0.2222
p.R345Q	SIDM01278	Colorectal Carcinoma	GDSC	LRDTPDGT	DEG_SCF_FBW7_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00459	Phosphatidylinositol 3-kinase regulatory subunit beta	DEG_SCF_FBW7_1	344:351	LRDTPDGT	FBXW7	0.9612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons