DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRETPHPE
Uniprot ID:
I3L273
Source protein:
Golgi-associated olfactory signaling regulator
Source gene:
GFY
Class:
DEG_SCF_FBW7_2
Location:
93:100
E3 ligase:
FBXW7
DEGRON score:
0.922
ASA_SCORE:
104.35
COIL:
0.9624
CONS_SCORE:
0
DSS_SCORE:
0.827
HELIX:
0.0142
FCONS_SCORE:
0
RIG_SCORE:
0.6038
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GFY mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRETPHPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
I3L273
Golgi-associated olfactory signaling regulator
DEG_SCF_FBW7_2
93:100
LRETPHPE
FBXW7
0.922
More...