DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRGLLARLP
Uniprot ID:
P84996
Source protein:
Protein ALEX
Source gene:
GNAS
Class:
DEG_APCC_DBOX_1
Location:
480:488
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8449
ASA_SCORE:
90.0778
COIL:
0.766
CONS_SCORE:
0.8335
DSS_SCORE:
0.371
HELIX:
0.206
FCONS_SCORE:
1.188
RIG_SCORE:
0.7587
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GNAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRGLLARLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P84996
Protein ALEX
DEG_APCC_DBOX_1
480:488
LRGLLARLP
APC,CDC20,FZR1
0.8449
More...