DegronMD

Uniprot ID: Q8WXF1

Source protein: Paraspeckle component 1

Source gene: PSPC1

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8854

ASA_SCORE: 69.1889

COIL: 0.5219

CONS_SCORE: 0.4058

DSS_SCORE: 0.5844

HELIX: 0.0038

FCONS_SCORE: 1.1519

RIG_SCORE: 0.7926

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R20C	TCGA-52-7809	LUSC	TCGA	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	TCGA-FD-A5BX	BLCA	TCGA	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	DO44079	BLCA	ICGC	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	DO26746	LUSC	ICGC	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	SIDM00796	Head and Neck Carcinoma	GDSC	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	ACH-000309	Lung Cancer	CCLE	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	ACH-000740	Head and Neck Cancer	CCLE	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	SK-LU-1	lung	COSMIC	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.R20C	A253	salivary_gland	COSMIC	LRGNLKQVR	DEG_APCC_DBOX_1	0.0833
p.N6H	TCGA-BR-8680	STAD	TCGA	LRGNLKQVR	DEG_APCC_DBOX_1	0.6312
p.N6H	DO47769	STAD	ICGC	LRGNLKQVR	DEG_APCC_DBOX_1	0.6312
p.R11S	DO44848	LICA	ICGC	LRGNLKQVR	DEG_APCC_DBOX_1	0.6316
p.N15T	DO229462	SKCA	ICGC	LRGNLKQVR	DEG_APCC_DBOX_1	0.2222
p.V10A	SIDM01609	Endometrial Carcinoma	GDSC	LRGNLKQVR	DEG_APCC_DBOX_1	0.6936
p.V10A	ACH-000972	Endometrial/Uterine Cancer	CCLE	LRGNLKQVR	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXF1	Paraspeckle component 1	DEG_APCC_DBOX_1	3:11	LRGNLKQVR	APC,CDC20,FZR1	0.8854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons