DegronMD

Uniprot ID: Q15008

Source protein: 26S proteasome non-ATPase regulatory subunit 6

Source gene: PSMD6

Class: DEG_APCC_DBOX_1

Location: 145:153

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5856

ASA_SCORE: 31.0556

COIL: 0.364

CONS_SCORE: 0.6645

DSS_SCORE: 0.0059

HELIX: 0.6138

FCONS_SCORE: 1.246

RIG_SCORE: 0.9811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K163N	TCGA-05-4382	LUAD	TCGA	LRIGLFYMD	DEG_APCC_DBOX_1	0.1667
p.R159Q	TCGA-B5-A1MR	UCEC	TCGA	LRIGLFYMD	DEG_APCC_DBOX_1	0.1667
p.R159Q	TCGA-DK-A6AW	BLCA	TCGA	LRIGLFYMD	DEG_APCC_DBOX_1	0.1667
p.R159Q	DO48566	BLCA	ICGC	LRIGLFYMD	DEG_APCC_DBOX_1	0.1667
p.R159Q	DO41758	UCEC	ICGC	LRIGLFYMD	DEG_APCC_DBOX_1	0.1667
p.R159Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	LRIGLFYMD	DEG_APCC_DBOX_1	0.1667
p.L144F	TCGA-ZF-AA52	BLCA	TCGA	LRIGLFYMD	DEG_APCC_DBOX_1	0.3056
p.L144F	DO219095	BLCA	ICGC	LRIGLFYMD	DEG_APCC_DBOX_1	0.3056
p.K157Q	DO4012	BRCA	ICGC	LRIGLFYMD	DEG_APCC_DBOX_1	0.2222
p.T158K	DO229018	LICA	ICGC	LRIGLFYMD	DEG_APCC_DBOX_1	0.1944
p.A160G	DO48757	LIRI	ICGC	LRIGLFYMD	DEG_APCC_DBOX_1	0.1389
p.G147C	DO222342	STAD	ICGC	LRIGLFYMD	DEG_APCC_DBOX_1	0.76
p.I153V	SIDM00853	Other Sarcomas	GDSC	LRIGLFYMD	DEG_APCC_DBOX_1	0.7076
p.I153V	GCT	soft_tissue	COSMIC	LRIGLFYMD	DEG_APCC_DBOX_1	0.7076
p.R136H	SIDM00118	Colorectal Carcinoma	GDSC	LRIGLFYMD	DEG_APCC_DBOX_1	0.0833
p.R136H	HCC2998	large_intestine	COSMIC	LRIGLFYMD	DEG_APCC_DBOX_1	0.0833
p.Q146R	CCK-81	large_intestine	COSMIC	LRIGLFYMD	DEG_APCC_DBOX_1	0.7329
p.D137E	HCC-366	lung	COSMIC	LRIGLFYMD	DEG_APCC_DBOX_1	0.1111
p.Q145R	CCK-81	large_intestine	COSMIC	LRIGLFYMD	DEG_APCC_DBOX_1	0.7329
p.D136E	HCC-366	lung	COSMIC	LRIGLFYMD	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15008	26S proteasome non-ATPase regulatory subunit 6	DEG_APCC_DBOX_1	145:153	LRIGLFYMD	APC,CDC20,FZR1	0.5856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons