DegronMD

Uniprot ID: P00748

Source protein: Coagulation factor XII

Source gene: F12

Class: DEG_APCC_DBOX_1

Location: 363:371

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9284

ASA_SCORE: 84.2444

COIL: 0.7946

CONS_SCORE: 0.5586

DSS_SCORE: 0.3177

HELIX: 0.1241

FCONS_SCORE: 0.7673

RIG_SCORE: 0.7504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G360W	TCGA-EE-A2MM	SKCM	TCGA	LRKSLSSMT	DEG_APCC_DBOX_1	0.25
p.G360W	DO37770	SKCM	ICGC	LRKSLSSMT	DEG_APCC_DBOX_1	0.25
p.R381H	DO23468	LINC	ICGC	LRKSLSSMT	DEG_APCC_DBOX_1	0.0556
p.S366N	SIDM01591	Breast Carcinoma	GDSC	LRKSLSSMT	DEG_APCC_DBOX_1	0.7069
p.S366N	ACH-000540	Non-Cancerous	CCLE	LRKSLSSMT	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00748	Coagulation factor XII	DEG_APCC_DBOX_1	363:371	LRKSLSSMT	APC,CDC20,FZR1	0.9284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons