DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRLALDQLS
Uniprot ID:
Q86XN8
Source protein:
RNA-binding protein MEX3D
Source gene:
MEX3D
Class:
DEG_APCC_DBOX_1
Location:
59:67
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8831
ASA_SCORE:
75.3778
COIL:
0.2263
CONS_SCORE:
0.3935
DSS_SCORE:
0.4647
HELIX:
0.761
FCONS_SCORE:
1.2855
RIG_SCORE:
0.8094
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MEX3D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRLALDQLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86XN8
RNA-binding protein MEX3D
DEG_APCC_DBOX_1
59:67
LRLALDQLS
APC,CDC20,FZR1
0.8831
More...