DegronMD

Uniprot ID: P35354

Source protein: Prostaglandin G/H synthase 2

Source gene: PTGS2

Class: LIG_APCC_ABBA_1

Location: 230:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7839

ASA_SCORE: 71.5

COIL: 0.5087

CONS_SCORE: 0.751

DSS_SCORE: 0.2564

HELIX: 0.1478

FCONS_SCORE: 1.2494

RIG_SCORE: 0.8565

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L232I	TCGA-44-7662	LUAD	TCGA	LRLFKD	LIG_APCC_ABBA_1	0.6063
p.L232I	DO23597	LUAD	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.6063
p.R231H	TCGA-AP-A0LM	UCEC	TCGA	LRLFKD	LIG_APCC_ABBA_1	0.7133
p.R231H	TCGA-CA-6717	COAD	TCGA	LRLFKD	LIG_APCC_ABBA_1	0.7133
p.R231H	DO8264	COAD	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.7133
p.R231H	DO43306	UCEC	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.7133
p.R228H	TCGA-BH-A0DD	BRCA	TCGA	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228H	TCGA-P6-A5OG	ACC	TCGA	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228H	DO2008	BRCA	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228H	SIDM00435	Acute Myeloid Leukemia	GDSC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228H	SIDM00618	Hepatocellular Carcinoma	GDSC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228H	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228H	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R231C	TCGA-E9-A1QZ	BRCA	TCGA	LRLFKD	LIG_APCC_ABBA_1	0.719
p.R231C	DO4737	BRCA	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.719
p.R231C	DO33344	PACA	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.719
p.R231C	SIDM00214	Colorectal Carcinoma	GDSC	LRLFKD	LIG_APCC_ABBA_1	0.719
p.R231C	ACH-000955	Colon/Colorectal Cancer	CCLE	LRLFKD	LIG_APCC_ABBA_1	0.719
p.R231C	SNU-407	large_intestine	COSMIC	LRLFKD	LIG_APCC_ABBA_1	0.719
p.R228C	TCGA-XK-AAIW	PRAD	TCGA	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228C	DO51407	PRAD	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228C	SIDM00217	Colorectal Carcinoma	GDSC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228C	ACH-000999	Colon/Colorectal Cancer	CCLE	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228C	SNU-1040	large_intestine	COSMIC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.R228S	DO231965	LICA	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.2778
p.Q227K	DO229018	LICA	ICGC	LRLFKD	LIG_APCC_ABBA_1	0.25
p.Y240C	SIDM01113	Other Sarcomas	GDSC	LRLFKD	LIG_APCC_ABBA_1	0.1944
p.Y240C	ACH-000939	Sarcoma	CCLE	LRLFKD	LIG_APCC_ABBA_1	0.1944
p.Y240C	SK-UT-1	soft_tissue	COSMIC	LRLFKD	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRLFKD

Degron related mutations and impact score

Drug responses associated with PTGS2 mutations

All proteins holding degron of LRLFKD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35354	Prostaglandin G/H synthase 2	LIG_APCC_ABBA_1	230:235	LRLFKD	APC,CDC20,FZR1	0.7839	More...