DegronMD

Uniprot ID: Q9Y4P1

Source protein: Cysteine protease ATG4B

Source gene: ATG4B

Class: DEG_APCC_DBOX_1

Location: 228:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8756

ASA_SCORE: 54.9889

COIL: 0.7032

CONS_SCORE: 0.6773

DSS_SCORE: 0.0401

HELIX: 0.1039

FCONS_SCORE: 1.2293

RIG_SCORE: 0.8615

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R229H	TCGA-AP-A1DV	UCEC	TCGA	LRLGLTDIN	DEG_APCC_DBOX_1	0.8244
p.R229H	TCGA-EO-A22U	UCEC	TCGA	LRLGLTDIN	DEG_APCC_DBOX_1	0.8244
p.T233R	TCGA-IG-A97H	ESCA	TCGA	LRLGLTDIN	DEG_APCC_DBOX_1	0.6765
p.P230S	DO229027	LICA	ICGC	LRLGLTDIN	DEG_APCC_DBOX_1	0.6752
p.A244T	DO41008	UCEC	ICGC	LRLGLTDIN	DEG_APCC_DBOX_1	0.2222
p.A237V	DO43891	UCEC	ICGC	LRLGLTDIN	DEG_APCC_DBOX_1	0.3056
p.V223L	SIDM00652	Small Cell Lung Carcinoma	GDSC	LRLGLTDIN	DEG_APCC_DBOX_1	0.1944
p.V223L	ACH-000780	Lung Cancer	CCLE	LRLGLTDIN	DEG_APCC_DBOX_1	0.1944
p.V223L	NCI-H1105	lung	COSMIC	LRLGLTDIN	DEG_APCC_DBOX_1	0.1944
p.T242M	ACH-000897	Thyroid Cancer	CCLE	LRLGLTDIN	DEG_APCC_DBOX_1	0.1667
p.H226R	AN3-CA	endometrium	COSMIC	LRLGLTDIN	DEG_APCC_DBOX_1	0.2778
p.D240Y	HT55	large_intestine	COSMIC	LRLGLTDIN	DEG_APCC_DBOX_1	0.2222
p.E238K	TT	thyroid	COSMIC	LRLGLTDIN	DEG_APCC_DBOX_1	0.2778
p.R233H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LRLGLTDIN	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4P1	Cysteine protease ATG4B	DEG_APCC_DBOX_1	228:236	LRLGLTDIN	APC,CDC20,FZR1	0.8756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons