DegronMD

Uniprot ID: P01137

Source protein: Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

Source gene: TGFB1

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7716

ASA_SCORE: 84.7889

COIL: 0.0611

CONS_SCORE: 0.52

DSS_SCORE: 0.0142

HELIX: 0.9311

FCONS_SCORE: 1.2707

RIG_SCORE: 0.957

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P10L	DO230334	COCA	ICGC	LRLLLLLLP	DEG_APCC_DBOX_1	0.7582
p.P10L	DO229016	COCA	ICGC	LRLLLLLLP	DEG_APCC_DBOX_1	0.7582
p.P10L	DO229005	COCA	ICGC	LRLLLLLLP	DEG_APCC_DBOX_1	0.7582
p.P10L	DO229346	LAML	ICGC	LRLLLLLLP	DEG_APCC_DBOX_1	0.7582
p.P10L	DO228947	LICA	ICGC	LRLLLLLLP	DEG_APCC_DBOX_1	0.7582
p.W17L	DO232838	NACA	ICGC	LRLLLLLLP	DEG_APCC_DBOX_1	0.25
p.V20M	SIDM01169	Ovarian Carcinoma	GDSC	LRLLLLLLP	DEG_APCC_DBOX_1	0.1667

Drug responses associated with TGFB1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R141Q (No)	GDSC	A-83-01	34.7926
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R141Q (No)	GDSC	LY2109761	58.006
SIDM00951	LAML\|acute_myeloid_leukaemia	p.E119K (No)	GDSC	A-83-01	34.7926
SIDM00951	LAML\|acute_myeloid_leukaemia	p.E119K (No)	GDSC	LY2109761	58.006
SIDM01090	COREAD\|large_intestine	p.R205L (No)	GDSC	A-83-01	114.3614
SIDM01090	COREAD\|large_intestine	p.R205L (No)	GDSC	LY2109761	231.89
SIDM00056	THCA\|thyroid	p.R296Q (No)	GDSC	A-83-01	65.1521
SIDM00056	THCA\|thyroid	p.R296Q (No)	GDSC	LY2109761	88.982
SIDM00217	COREAD\|large_intestine	p.G307D (No)	GDSC	A-83-01	33.8516
SIDM00217	COREAD\|large_intestine	p.G307D (No)	GDSC	LY2109761	142.56
SIDM00217	COREAD\|large_intestine	p.R296Q (No)	GDSC	A-83-01	33.8516
SIDM00217	COREAD\|large_intestine	p.R296Q (No)	GDSC	LY2109761	142.56
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.T289A (No)	GDSC	A-83-01	28.9039
SIDM00889	CESC\|cervix	p.A221T (No)	GDSC	A-83-01	18.789
SIDM00889	CESC\|cervix	p.A221T (No)	GDSC	LY2109761	195.19
SIDM00216	COREAD\|large_intestine	p.A221T (No)	GDSC	A-83-01	50.1231
SIDM00216	COREAD\|large_intestine	p.A221T (No)	GDSC	LY2109761	76.426
SIDM00216	COREAD\|large_intestine	p.R218H (No)	GDSC	A-83-01	50.1231
SIDM00216	COREAD\|large_intestine	p.R218H (No)	GDSC	LY2109761	76.426
SIDM01052	OV\|ovary	p.R152Q (No)	GDSC	A-83-01	51.2521
SIDM01052	OV\|ovary	p.R152Q (No)	GDSC	LY2109761	1627
SIDM00783	COREAD\|large_intestine	p.Y103H (No)	GDSC	A-83-01	37.9306
SIDM00783	COREAD\|large_intestine	p.Y103H (No)	GDSC	LY2109761	111.43
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.E169* (No)	GDSC	A-83-01	251.5153
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.E169* (No)	GDSC	LY2109761	361.46
SIDM00609	KIRC\|kidney	p.I300V (No)	GDSC	A-83-01	48.0769
SIDM00609	KIRC\|kidney	p.I300V (No)	GDSC	LY2109761	244.57
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R243C (No)	GDSC	A-83-01	24.1591
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R243C (No)	GDSC	LY2109761	142.59
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.S209R (No)	GDSC	A-83-01	31.6981
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.S209R (No)	GDSC	LY2109761	87.565
SIDM00332	BRCA\|breast	p.S138L (No)	GDSC	A-83-01	41.1938
SIDM00332	BRCA\|breast	p.S138L (No)	GDSC	LY2109761	3335.6
SIDM00193	COREAD\|large_intestine	p.F134L (No)	GDSC	A-83-01	95.3954
SIDM00193	COREAD\|large_intestine	p.F134L (No)	GDSC	LY2109761	114.68
SIDM00661	DLBC\|B_cell_lymphoma	p.H276fs*107 (No)	GDSC	A-83-01	51.6613

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRLLLLLLP

Degron related mutations and impact score

Drug responses associated with TGFB1 mutations

All proteins holding degron of LRLLLLLLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01137	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide	DEG_APCC_DBOX_1	6:14	LRLLLLLLP	APC,CDC20,FZR1	0.7716	More...