DegronMD

Uniprot ID: P48546

Source protein: Gastric inhibitory polypeptide receptor

Source gene: GIPR

Class: DEG_APCC_DBOX_1

Location: 11:19

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7137

ASA_SCORE: 51.5444

COIL: 0.087

CONS_SCORE: 0.3271

DSS_SCORE: 0.0359

HELIX: 0.9083

FCONS_SCORE: 1.2047

RIG_SCORE: 0.9047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T25S	TCGA-G4-6320	COAD	TCGA	LRLSLCGLL	DEG_APCC_DBOX_1	0.1667
p.T25S	DO8159	COAD	ICGC	LRLSLCGLL	DEG_APCC_DBOX_1	0.1667
p.G26V	DO229024	LICA	ICGC	LRLSLCGLL	DEG_APCC_DBOX_1	0.1389
p.R12L	DO229041	LICA	ICGC	LRLSLCGLL	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48546	Gastric inhibitory polypeptide receptor	DEG_APCC_DBOX_1	11:19	LRLSLCGLL	APC,CDC20,FZR1	0.7137	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons