DegronMD

Uniprot ID: O95477

Source protein: Phospholipid-transporting ATPase ABCA1

Source gene: ABCA1

Class: LIG_APCC_ABBA_1

Location: 1282:1287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7697

ASA_SCORE: 88.4

COIL: 0.844

CONS_SCORE: 0.2478

DSS_SCORE: 0.627

HELIX: 0.0565

FCONS_SCORE: 0.973

RIG_SCORE: 0.7087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1288Y	TCGA-33-4566	LUSC	TCGA	LRPFTE	LIG_APCC_ABBA_1	0.3056
p.D1288Y	DO26790	LUSC	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.3056
p.D1295Y	TCGA-D1-A103	UCEC	TCGA	LRPFTE	LIG_APCC_ABBA_1	0.1111
p.D1295Y	DO42312	UCEC	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.1111
p.G1276R	TCGA-EO-A22R	UCEC	TCGA	LRPFTE	LIG_APCC_ABBA_1	0.1667
p.G1276R	DO42713	UCEC	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.1667
p.G1276R	ACH-001610	Brain Cancer	CCLE	LRPFTE	LIG_APCC_ABBA_1	0.1667
p.R1283C	TCGA-RS-A6TO	HNSC	TCGA	LRPFTE	LIG_APCC_ABBA_1	0.719
p.R1283C	DO219060	HNSC	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.719
p.R1283H	DO222501	COCA	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.7133
p.L1282I	DO228976	LICA	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.6063
p.Q1279K	DO229027	LICA	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.25
p.D1277G	DO229485	SKCA	ICGC	LRPFTE	LIG_APCC_ABBA_1	0.1944
p.D1289N	SIDM00383	Gastric Carcinoma	GDSC	LRPFTE	LIG_APCC_ABBA_1	0.2778
p.D1289N	SIDM00240	Cervical Carcinoma	GDSC	LRPFTE	LIG_APCC_ABBA_1	0.2778
p.D1289N	ACH-002021	Endometrial/Uterine Cancer	CCLE	LRPFTE	LIG_APCC_ABBA_1	0.2778
p.D1289N	ACH-002180	Cervical Cancer	CCLE	LRPFTE	LIG_APCC_ABBA_1	0.2778
p.D1289N	ACH-002198	Gastric Cancer	CCLE	LRPFTE	LIG_APCC_ABBA_1	0.2778
p.D1289N	SCH	stomach	COSMIC	LRPFTE	LIG_APCC_ABBA_1	0.2778
p.D1289N	OMC-1	cervix	COSMIC	LRPFTE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95477	Phospholipid-transporting ATPase ABCA1	LIG_APCC_ABBA_1	1282:1287	LRPFTE	APC,CDC20,FZR1	0.7697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons