DegronMD

Uniprot ID: P12980

Source protein: Protein lyl-1

Source gene: LYL1

Class: DEG_APCC_DBOX_1

Location: 83:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9694

ASA_SCORE: 71.4667

COIL: 0.8199

CONS_SCORE: 0.3701

DSS_SCORE: 0.4293

HELIX: 0.1236

FCONS_SCORE: 0.8178

RIG_SCORE: 0.7806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S91C	TCGA-A2-A0YM	BRCA	TCGA	LRPPLLQLS	DEG_APCC_DBOX_1	0.643
p.S91C	DO1842	BRCA	ICGC	LRPPLLQLS	DEG_APCC_DBOX_1	0.643
p.P97S	TCGA-A5-A2K5	UCEC	TCGA	LRPPLLQLS	DEG_APCC_DBOX_1	0.1667
p.P97S	DO41379	UCEC	ICGC	LRPPLLQLS	DEG_APCC_DBOX_1	0.1667
p.P86L	TCGA-L5-A8NM	ESCA	TCGA	LRPPLLQLS	DEG_APCC_DBOX_1	0.6471
p.T78K	DO228978	LICA	ICGC	LRPPLLQLS	DEG_APCC_DBOX_1	0.1944
p.A101D	DO229036	LICA	ICGC	LRPPLLQLS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12980	Protein lyl-1	DEG_APCC_DBOX_1	83:91	LRPPLLQLS	APC,CDC20,FZR1	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons