DegronMD

Uniprot ID: O43272

Source protein: Proline dehydrogenase 1, mitochondrial

Source gene: PRODH

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8838

ASA_SCORE: 99.1

COIL: 0.8322

CONS_SCORE: 0.2516

DSS_SCORE: 0.4396

HELIX: 0.1151

FCONS_SCORE: 0.9078

RIG_SCORE: 0.7987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19Q	DO229013	COCA	ICGC	LRRALPALR	DEG_APCC_DBOX_1	0.1111
p.P19Q	DO229016	COCA	ICGC	LRRALPALR	DEG_APCC_DBOX_1	0.1111
p.F5L	DO222415	MELA	ICGC	LRRALPALR	DEG_APCC_DBOX_1	0.6981
p.A9V	DO46909	RECA	ICGC	LRRALPALR	DEG_APCC_DBOX_1	0.5825
p.F5V	DO42280	UCEC	ICGC	LRRALPALR	DEG_APCC_DBOX_1	0.7068
p.A6T	ACH-000223	Breast Cancer	CCLE	LRRALPALR	DEG_APCC_DBOX_1	0.6028
p.P8S	ACH-000665	Lung Cancer	CCLE	LRRALPALR	DEG_APCC_DBOX_1	0.5641
p.R5H	ACH-000852	Lung Cancer	CCLE	LRRALPALR	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43272	Proline dehydrogenase 1, mitochondrial	DEG_APCC_DBOX_1	3:11	LRRALPALR	APC,CDC20,FZR1	0.8838	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons