DegronMD

Uniprot ID: Q86WX3

Source protein: Active regulator of SIRT1

Source gene: RPS19BP1

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8001

ASA_SCORE: 53.8556

COIL: 0.2431

CONS_SCORE: 0.7608

DSS_SCORE: 0.528

HELIX: 0.7467

FCONS_SCORE: 1.3624

RIG_SCORE: 0.7584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P22L	TCGA-WE-A8ZT	SKCM	TCGA	LRRGLELLA	DEG_APCC_DBOX_1	0.1111
p.P22L	DO51290	SKCM	ICGC	LRRGLELLA	DEG_APCC_DBOX_1	0.1111
p.P22L	SIDM00235	Kidney Carcinoma	GDSC	LRRGLELLA	DEG_APCC_DBOX_1	0.1111
p.P22L	SIDM00171	Colorectal Carcinoma	GDSC	LRRGLELLA	DEG_APCC_DBOX_1	0.1111
p.P22L	RCC10RGB	kidney	COSMIC	LRRGLELLA	DEG_APCC_DBOX_1	0.1111
p.D21E	DO229025	LICA	ICGC	LRRGLELLA	DEG_APCC_DBOX_1	0.1389
p.E17K	DO232042	ORCA	ICGC	LRRGLELLA	DEG_APCC_DBOX_1	0.25
p.P22S	SIDM00720	Mesothelioma	GDSC	LRRGLELLA	DEG_APCC_DBOX_1	0.1111
p.P22S	SIDM01664	Prostate Carcinoma	GDSC	LRRGLELLA	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WX3	Active regulator of SIRT1	DEG_APCC_DBOX_1	6:14	LRRGLELLA	APC,CDC20,FZR1	0.8001	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons