DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LRRPLFSLK
Uniprot ID:
H3BV60
Source protein:
Transforming growth factor-beta receptor type 3-like protein
Source gene:
TGFBR3L
Class:
DEG_APCC_DBOX_1
Location:
58:66
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.555
ASA_SCORE:
50.3333
COIL:
0.4409
CONS_SCORE:
0.9168
DSS_SCORE:
0.3297
HELIX:
0.0201
FCONS_SCORE:
1.2215
RIG_SCORE:
0.7807
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T70K
DO233828
GACA
ICGC
LRRPLFSLK
DEG_APCC_DBOX_1
0.2222
p.R60G
DO229188
THCA
ICGC
LRRPLFSLK
DEG_APCC_DBOX_1
0.6457
Drug responses associated with TGFBR3L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRRPLFSLK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
H3BV60
Transforming growth factor-beta receptor type 3-like protein
DEG_APCC_DBOX_1
58:66
LRRPLFSLK
APC,CDC20,FZR1
0.555
More...