DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRRVLHDIR
Uniprot ID:
P28290
Source protein:
Protein ITPRID2
Source gene:
ITPRID2
Class:
DEG_APCC_DBOX_1
Location:
913:921
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8965
ASA_SCORE:
105.2556
COIL:
0.5886
CONS_SCORE:
0.6044
DSS_SCORE:
0.3704
HELIX:
0.3484
FCONS_SCORE:
1.1513
RIG_SCORE:
0.8404
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V916I
SIDM01588
Endometrial Carcinoma
GDSC
LRRVLHDIR
DEG_APCC_DBOX_1
0.5965
Drug responses associated with ITPRID2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRRVLHDIR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P28290
Protein ITPRID2
DEG_APCC_DBOX_1
913:921
LRRVLHDIR
APC,CDC20,FZR1
0.8965
More...