DegronMD

Uniprot ID: Q9Y4C4

Source protein: Malignant fibrous histiocytoma-amplified sequence 1

Source gene: MFHAS1

Class: DEG_APCC_DBOX_1

Location: 25:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9399

ASA_SCORE: 72.3

COIL: 0.6602

CONS_SCORE: 0.4584

DSS_SCORE: 0.2768

HELIX: 0.229

FCONS_SCORE: 1.2154

RIG_SCORE: 0.7978

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R30L	ACH-001648	Prostate Cancer	CCLE	LRSNLRQLT	DEG_APCC_DBOX_1	0.7316
p.R30H	TCGA-R6-A8W5	ESCA	TCGA	LRSNLRQLT	DEG_APCC_DBOX_1	0.7133
p.S27I	DO230309	COCA	ICGC	LRSNLRQLT	DEG_APCC_DBOX_1	0.623
p.Q31R	ACH-001382	Pancreatic Cancer	CCLE	LRSNLRQLT	DEG_APCC_DBOX_1	0.6218
p.A22D	ACH-001669	Leukemia	CCLE	LRSNLRQLT	DEG_APCC_DBOX_1	0.25
p.A37V	ACH-000999	Colon/Colorectal Cancer	CCLE	LRSNLRQLT	DEG_APCC_DBOX_1	0.2222
p.C40F	SIDM00232	Kidney Carcinoma	GDSC	LRSNLRQLT	DEG_APCC_DBOX_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4C4	Malignant fibrous histiocytoma-amplified sequence 1	DEG_APCC_DBOX_1	25:33	LRSNLRQLT	APC,CDC20,FZR1	0.9399	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons