DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRSNLRQLT
Uniprot ID:
Q9Y4C4
Source protein:
Malignant fibrous histiocytoma-amplified sequence 1
Source gene:
MFHAS1
Class:
DEG_APCC_DBOX_1
Location:
25:33
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9399
ASA_SCORE:
72.3
COIL:
0.6602
CONS_SCORE:
0.4584
DSS_SCORE:
0.2768
HELIX:
0.229
FCONS_SCORE:
1.2154
RIG_SCORE:
0.7978
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R30H
TCGA-R6-A8W5
ESCA
TCGA
LRSNLRQLT
DEG_APCC_DBOX_1
0.7133
p.S27I
DO230309
COCA
ICGC
LRSNLRQLT
DEG_APCC_DBOX_1
0.623
p.C40F
SIDM00232
Kidney Carcinoma
GDSC
LRSNLRQLT
DEG_APCC_DBOX_1
0.1389
p.A37V
ACH-000999
Colon/Colorectal Cancer
CCLE
LRSNLRQLT
DEG_APCC_DBOX_1
0.2222
p.Q31R
ACH-001382
Pancreatic Cancer
CCLE
LRSNLRQLT
DEG_APCC_DBOX_1
0.6218
p.R30L
ACH-001648
Prostate Cancer
CCLE
LRSNLRQLT
DEG_APCC_DBOX_1
0.7316
p.A22D
ACH-001669
Leukemia
CCLE
LRSNLRQLT
DEG_APCC_DBOX_1
0.25
Drug responses associated with MFHAS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRSNLRQLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4C4
Malignant fibrous histiocytoma-amplified sequence 1
DEG_APCC_DBOX_1
25:33
LRSNLRQLT
APC,CDC20,FZR1
0.9399
More...