DegronMD

Uniprot ID: Q15935

Source protein: Zinc finger protein 77

Source gene: ZNF77

Class: DEG_APCC_DBOX_1

Location: 103:111

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7891

ASA_SCORE: 91.0444

COIL: 0.7303

CONS_SCORE: 0.5135

DSS_SCORE: 0.4071

HELIX: 0.1043

FCONS_SCORE: 1.1146

RIG_SCORE: 0.7195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C111R	TCGA-DU-6392	LGG	TCGA	LRSQLGRLC	DEG_APCC_DBOX_1	0.719
p.C111R	DO22237	LGG	ICGC	LRSQLGRLC	DEG_APCC_DBOX_1	0.719
p.G116S	SIDM00933	Breast Carcinoma	GDSC	LRSQLGRLC	DEG_APCC_DBOX_1	0.1944
p.G116S	ACH-000856	Breast Cancer	CCLE	LRSQLGRLC	DEG_APCC_DBOX_1	0.1944
p.G116S	CAL-51	breast	COSMIC	LRSQLGRLC	DEG_APCC_DBOX_1	0.1944
p.P99S	SIDM00908	Non-Cancerous	GDSC	LRSQLGRLC	DEG_APCC_DBOX_1	0.2222
p.P99S	SIDM00909	Melanoma	GDSC	LRSQLGRLC	DEG_APCC_DBOX_1	0.2222
p.P99S	ACH-000644	Skin Cancer	CCLE	LRSQLGRLC	DEG_APCC_DBOX_1	0.2222
p.P99S	ACH-002380	Non-Cancerous	CCLE	LRSQLGRLC	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15935	Zinc finger protein 77	DEG_APCC_DBOX_1	103:111	LRSQLGRLC	APC,CDC20,FZR1	0.7891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons