DegronMD

Uniprot ID: P46937

Source protein: Transcriptional coactivator YAP1

Source gene: YAP1

Class: DEG_APCC_DBOX_1

Location: 348:356

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9536

ASA_SCORE: 74.2444

COIL: 0.5118

CONS_SCORE: 0.578

DSS_SCORE: 0.6448

HELIX: 0.4051

FCONS_SCORE: 1.0275

RIG_SCORE: 0.6952

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q344K	TCGA-66-2765	LUSC	TCGA	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.Q344K	DO26761	LUSC	ICGC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.N339H	TCGA-DF-A2KV	UCEC	TCGA	LRSQLPTLE	DEG_APCC_DBOX_1	0.0833
p.N339H	DO219771	UCEC	ICGC	LRSQLPTLE	DEG_APCC_DBOX_1	0.0833
p.P341A	TCGA-HE-7130	KIRP	TCGA	LRSQLPTLE	DEG_APCC_DBOX_1	0.1389
p.P341A	DO20776	KIRP	ICGC	LRSQLPTLE	DEG_APCC_DBOX_1	0.1389
p.S366C	TCGA-IG-A3Y9	ESCA	TCGA	LRSQLPTLE	DEG_APCC_DBOX_1	0.5
p.G359C	DO228976	LICA	ICGC	LRSQLPTLE	DEG_APCC_DBOX_1	0.25
p.S350N	DO229268	THCA	ICGC	LRSQLPTLE	DEG_APCC_DBOX_1	0.5958
p.Q361P	SIDM00973	Melanoma	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.6389
p.Q361P	WM793B	skin	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.6389
p.S344A	SIDM00845	Burkitt's Lymphoma	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.S344A	SIDM00035	Thyroid Gland Carcinoma	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.S344A	SIDM00461	Acute Myeloid Leukemia	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.S344A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.S344A	SIDM01519	Head and Neck Carcinoma	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.S344A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.S344A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.E360D	SIDM01044	Other Solid Cancers	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.E360D	EPLC-272H	lung	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.A351S	SIDM01077	Prostate Carcinoma	GDSC	LRSQLPTLE	DEG_APCC_DBOX_1	0.7588
p.A351S	VCaP	prostate	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.7588
p.A347S	VCaP	prostate	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.3056
p.S340A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.5556
p.S340A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.5556
p.E340D	EPLC-272H	lung	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.5556
p.E344D	EPLC-272H	lung	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.2222
p.Q341P	WM793B	skin	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.1389
p.Q357P	WM793B	skin	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.3056
p.M361I	NCI-H2023	lung	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.6389
p.M365I	NCI-H2023	lung	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.0833
p.M343I	NCI-H2023	lung	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.1944
p.D349A	HCC1599	breast	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.7793
p.E356D	EPLC-272H	lung	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.5647
p.Q345P	WM793B	skin	COSMIC	LRSQLPTLE	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRSQLPTLE

Degron related mutations and impact score

Drug responses associated with YAP1 mutations

All proteins holding degron of LRSQLPTLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46937	Transcriptional coactivator YAP1	DEG_APCC_DBOX_1	348:356	LRSQLPTLE	APC,CDC20,FZR1	0.9536	More...