DegronMD

Uniprot ID: Q6P1J6

Source protein: Phospholipase B1, membrane-associated

Source gene: PLB1

Class: DEG_SCF_FBW7_1

Location: 1048:1054

E3 ligase: FBXW7

DEGRON score: 0.961

ASA_SCORE: 80.9429

COIL: 0.7724

CONS_SCORE: 0.4717

DSS_SCORE: 0.4346

HELIX: 0.071

FCONS_SCORE: 1.0743

RIG_SCORE: 0.75

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1052L	TCGA-AX-A0J0	UCEC	TCGA	LRTPRNS	DEG_SCF_FBW7_1	0.7316
p.R1052L	DO41133	UCEC	ICGC	LRTPRNS	DEG_SCF_FBW7_1	0.7316
p.R1052W	TCGA-EE-A29H	SKCM	TCGA	LRTPRNS	DEG_SCF_FBW7_1	0.7523
p.R1052W	DO37535	SKCM	ICGC	LRTPRNS	DEG_SCF_FBW7_1	0.7523
p.I1064M	TCGA-EO-A22U	UCEC	TCGA	LRTPRNS	DEG_SCF_FBW7_1	0.0556
p.I1064M	DO43755	UCEC	ICGC	LRTPRNS	DEG_SCF_FBW7_1	0.0556
p.Y1058H	TCGA-G2-AA3B	BLCA	TCGA	LRTPRNS	DEG_SCF_FBW7_1	0.2222
p.Y1058H	DO51882	BLCA	ICGC	LRTPRNS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1J6	Phospholipase B1, membrane-associated	DEG_SCF_FBW7_1	1048:1054	LRTPRNS	FBXW7	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons