DegronMD

Uniprot ID: P19876

Source protein: C-X-C motif chemokine 3

Source gene: CXCL3

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6875

ASA_SCORE: 46.8111

COIL: 0.0027

CONS_SCORE: 0.5403

DSS_SCORE: 0.0094

HELIX: 0.9963

FCONS_SCORE: 1.5783

RIG_SCORE: 0.9767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R31H	TCGA-AJ-A8CW	UCEC	TCGA	LRVALLLLL	DEG_APCC_DBOX_1	0.1389
p.R31H	DO52400	UCEC	ICGC	LRVALLLLL	DEG_APCC_DBOX_1	0.1389
p.R31H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LRVALLLLL	DEG_APCC_DBOX_1	0.1389
p.R31H	ACH-000874	Leukemia	CCLE	LRVALLLLL	DEG_APCC_DBOX_1	0.1389
p.R31H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	LRVALLLLL	DEG_APCC_DBOX_1	0.1389
p.R30Q	TCGA-D9-A6EC	SKCM	TCGA	LRVALLLLL	DEG_APCC_DBOX_1	0.1667
p.R30Q	DO50291	SKCM	ICGC	LRVALLLLL	DEG_APCC_DBOX_1	0.1667
p.S11R	DO229003	COCA	ICGC	LRVALLLLL	DEG_APCC_DBOX_1	0.1944
p.A32S	DO229268	THCA	ICGC	LRVALLLLL	DEG_APCC_DBOX_1	0.1111
p.A28T	DO229268	THCA	ICGC	LRVALLLLL	DEG_APCC_DBOX_1	0.2222
p.G34A	SIDM00009	Acute Myeloid Leukemia	GDSC	LRVALLLLL	DEG_APCC_DBOX_1	0.0556
p.G34A	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	LRVALLLLL	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19876	C-X-C motif chemokine 3	DEG_APCC_DBOX_1	16:24	LRVALLLLL	APC,CDC20,FZR1	0.6875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons