DegronMD

Uniprot ID: P17658

Source protein: Potassium voltage-gated channel subfamily A member 6

Source gene: KCNA6

Class: LIG_APCC_ABBA_1

Location: 59:64

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7086

ASA_SCORE: 55.0167

COIL: 0.6475

CONS_SCORE: 0.4579

DSS_SCORE: 0.1978

HELIX: 0.3365

FCONS_SCORE: 1.1931

RIG_SCORE: 0.8483

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P70S	TCGA-3A-A9IV	PAAD	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.1667
p.P70S	DO218959	PAAD	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.1667
p.R57H	TCGA-55-7283	LUAD	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.2778
p.R57H	DO23606	LUAD	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.2778
p.E53Q	TCGA-60-2714	LUSC	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.1667
p.E53Q	DO26530	LUSC	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.1667
p.E53D	TCGA-68-8250	LUSC	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.1667
p.E53D	DO26993	LUSC	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.1667
p.R73Q	TCGA-BS-A0UV	UCEC	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.0833
p.R73Q	TCGA-FI-A2D5	UCEC	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.0833
p.R73Q	DO42793	UCEC	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.0833
p.R73Q	DO41331	UCEC	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.0833
p.R72W	TCGA-D1-A1NZ	UCEC	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.R72W	DO41536	UCEC	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.R51C	TCGA-EO-A3AU	UCEC	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.R51C	TCGA-VQ-A91D	STAD	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.R51C	DO51783	STAD	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.R51C	DO43827	UCEC	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.R72Q	TCGA-L5-A4OO	ESCA	TCGA	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.R57C	DO230343	COCA	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.2778
p.P63Q	DO50912	LICA	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.5924
p.G68R	DO220872	MELA	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.2222
p.P63S	DO35376	PACA	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.5641
p.R51H	DO51094	PRAD	ICGC	LSLFPD	LIG_APCC_ABBA_1	0.1111
p.S60T	ACH-000791	Lung Cancer	CCLE	LSLFPD	LIG_APCC_ABBA_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17658	Potassium voltage-gated channel subfamily A member 6	LIG_APCC_ABBA_1	59:64	LSLFPD	APC,CDC20,FZR1	0.7086	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons