DegronMD

Uniprot ID: Q96RR1

Source protein: Twinkle mtDNA helicase

Source gene: TWNK

Class: LIG_APCC_ABBA_1

Location: 81:86

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8763

ASA_SCORE: 42.55

COIL: 0.7343

CONS_SCORE: 0.6355

DSS_SCORE: 0.3101

HELIX: 0.0463

FCONS_SCORE: 1.3517

RIG_SCORE: 0.76

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S87F	SIDM01175	Other Sarcomas	GDSC	LSPFAE	LIG_APCC_ABBA_1	0.3056
p.S87F	SW684	soft_tissue	COSMIC	LSPFAE	LIG_APCC_ABBA_1	0.3056
p.L81V	SIDM00869	Non-Cancerous	GDSC	LSPFAE	LIG_APCC_ABBA_1	0.5654
p.L81V	SIDM00964	Non-Cancerous	GDSC	LSPFAE	LIG_APCC_ABBA_1	0.5654
p.A80T	SIDM00224	Mesothelioma	GDSC	LSPFAE	LIG_APCC_ABBA_1	0.3056
p.A80T	IST-MES1	pleura	COSMIC	LSPFAE	LIG_APCC_ABBA_1	0.3056
p.D94Y	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LSPFAE	LIG_APCC_ABBA_1	0.1111
p.N96S	SNU-1040	large_intestine	COSMIC	LSPFAE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RR1	Twinkle mtDNA helicase	LIG_APCC_ABBA_1	81:86	LSPFAE	APC,CDC20,FZR1	0.8763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons