DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LSPFWD
Uniprot ID:
Q5T8R8
Source protein:
Uncharacterized protein DOCK8-AS1
Source gene:
DOCK8-AS1
Class:
LIG_APCC_ABBA_1
Location:
15:20
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9415
ASA_SCORE:
48.5167
COIL:
0.835
CONS_SCORE:
0
DSS_SCORE:
0.4155
HELIX:
0.108
FCONS_SCORE:
0
RIG_SCORE:
0.7366
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DOCK8-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSPFWD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5T8R8
Uncharacterized protein DOCK8-AS1
LIG_APCC_ABBA_1
15:20
LSPFWD
APC,CDC20,FZR1
0.9415
More...