DegronMD

Uniprot ID: Q17R89

Source protein: Rho GTPase-activating protein 44

Source gene: ARHGAP44

Class: DEG_SCF_FBW7_1

Location: 679:686

E3 ligase: FBXW7

DEGRON score: 0.958

ASA_SCORE: 88.7375

COIL: 0.9651

CONS_SCORE: 0.3619

DSS_SCORE: 0.6683

HELIX: 0.0114

FCONS_SCORE: 1.0309

RIG_SCORE: 0.5365

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q696R	TCGA-BR-8363	STAD	TCGA	LSPTPPST	DEG_SCF_FBW7_1	0.0556
p.Q696R	DO47837	STAD	ICGC	LSPTPPST	DEG_SCF_FBW7_1	0.0556
p.G691E	TCGA-DA-A1IC	SKCM	TCGA	LSPTPPST	DEG_SCF_FBW7_1	0.1944
p.G691E	DO37430	SKCM	ICGC	LSPTPPST	DEG_SCF_FBW7_1	0.1944
p.P676T	TCGA-EE-A2M8	SKCM	TCGA	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676T	DO38075	SKCM	ICGC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.S678N	DO233885	GACA	ICGC	LSPTPPST	DEG_SCF_FBW7_1	0.3056
p.A671T	DO233882	GACA	ICGC	LSPTPPST	DEG_SCF_FBW7_1	0.1111
p.G672V	DO229041	LICA	ICGC	LSPTPPST	DEG_SCF_FBW7_1	0.1389
p.S693G	DO36556	READ	ICGC	LSPTPPST	DEG_SCF_FBW7_1	0.1389
p.P676L	SIDM00491	Thyroid Gland Carcinoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SIDM00781	Colorectal Carcinoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SIDM00057	Neuroblastoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SIDM00552	Rhabdomyosarcoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SIDM00350	Head and Neck Carcinoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SIDM00687	Gastric Carcinoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SIDM00580	Acute Myeloid Leukemia	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SIDM00780	Colorectal Carcinoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	KATOIII	stomach	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	ASH-3	thyroid	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	KYM-1	soft_tissue	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P676L	SAT	upper_aerodigestive_tract	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.25
p.P684T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LSPTPPST	DEG_SCF_FBW7_1	0.5919
p.P684T	ACH-000845	Lung Cancer	CCLE	LSPTPPST	DEG_SCF_FBW7_1	0.5919
p.T682P	ACH-001229	Primary	CCLE	LSPTPPST	DEG_SCF_FBW7_1	0.7031
p.P670L	SAT	upper_aerodigestive_tract	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.0833
p.P670L	KYM-1	soft_tissue	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.0833
p.P670L	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.0833
p.P670L	ASH-3	thyroid	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.0833
p.P670L	KATOIII	stomach	COSMIC	LSPTPPST	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSPTPPST

Degron related mutations and impact score

Drug responses associated with ARHGAP44 mutations

All proteins holding degron of LSPTPPST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17R89	Rho GTPase-activating protein 44	DEG_SCF_FBW7_1	679:686	LSPTPPST	FBXW7	0.958	More...