DegronMD

Uniprot ID: P18848

Source protein: Cyclic AMP-dependent transcription factor ATF-4

Source gene: ATF4

Class: DEG_SCF_FBW7_1

Location: 170:177

E3 ligase: FBXW7

DEGRON score: 0.9728

ASA_SCORE: 70.475

COIL: 0.8543

CONS_SCORE: 0.5493

DSS_SCORE: 0.4215

HELIX: 0.0631

FCONS_SCORE: 0.8832

RIG_SCORE: 0.6633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S171T	TCGA-AX-A2H2	UCEC	TCGA	LSSTPDHS	DEG_SCF_FBW7_1	0.6005
p.S171T	DO41959	UCEC	ICGC	LSSTPDHS	DEG_SCF_FBW7_1	0.6005
p.D175Y	TCGA-B5-A1MR	UCEC	TCGA	LSSTPDHS	DEG_SCF_FBW7_1	0.6214
p.D175Y	DO41758	UCEC	ICGC	LSSTPDHS	DEG_SCF_FBW7_1	0.6214
p.D187N	TCGA-CV-A6JD	HNSC	TCGA	LSSTPDHS	DEG_SCF_FBW7_1	0.0556
p.D187N	DO49035	HNSC	ICGC	LSSTPDHS	DEG_SCF_FBW7_1	0.0556
p.L170M	TCGA-D1-A177	UCEC	TCGA	LSSTPDHS	DEG_SCF_FBW7_1	0.5999
p.L170M	DO42528	UCEC	ICGC	LSSTPDHS	DEG_SCF_FBW7_1	0.5999
p.Q161L	DO222586	ESCA	ICGC	LSSTPDHS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18848	Cyclic AMP-dependent transcription factor ATF-4	DEG_SCF_FBW7_1	170:177	LSSTPDHS	FBXW7	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons