DegronMD

Uniprot ID: Q6UX07

Source protein: Dehydrogenase/reductase SDR family member 13

Source gene: DHRS13

Class: DEG_SCF_FBW7_2

Location: 336:342

E3 ligase: FBXW7

DEGRON score: 0.95

ASA_SCORE: 100.4143

COIL: 0.9524

CONS_SCORE: 0.3796

DSS_SCORE: 0.8788

HELIX: 0.0267

FCONS_SCORE: 1.0004

RIG_SCORE: 0.4735

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E331Q	TCGA-A1-A0SH	BRCA	TCGA	LSTPHPE	DEG_SCF_FBW7_2	0.1944
p.E331Q	DO1261	BRCA	ICGC	LSTPHPE	DEG_SCF_FBW7_2	0.1944
p.S334Y	TCGA-B5-A3FC	UCEC	TCGA	LSTPHPE	DEG_SCF_FBW7_2	0.2778
p.P341H	TCGA-HE-7128	KIRP	TCGA	LSTPHPE	DEG_SCF_FBW7_2	0.6583
p.A332T	TCGA-IB-7651	PAAD	TCGA	LSTPHPE	DEG_SCF_FBW7_2	0.2222
p.A332T	DO46657	PAAD	ICGC	LSTPHPE	DEG_SCF_FBW7_2	0.2222
p.L336Q	DO229505	LAML	ICGC	LSTPHPE	DEG_SCF_FBW7_2	0.7765
p.L336Q	DO228941	LICA	ICGC	LSTPHPE	DEG_SCF_FBW7_2	0.7765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX07	Dehydrogenase/reductase SDR family member 13	DEG_SCF_FBW7_2	336:342	LSTPHPE	FBXW7	0.95	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons