DegronMD

Uniprot ID: Q15858

Source protein: Sodium channel protein type 9 subunit alpha

Source gene: SCN9A

Class: DEG_SCF_FBW7_1

Location: 529:535

E3 ligase: FBXW7

DEGRON score: 0.8867

ASA_SCORE: 85.1143

COIL: 0.9007

CONS_SCORE: 0.2681

DSS_SCORE: 0.6063

HELIX: 0.0656

FCONS_SCORE: 0.9186

RIG_SCORE: 0.6481

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H525P	TCGA-05-4405	LUAD	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.2222
p.H525P	DO24656	LUAD	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.2222
p.A524T	TCGA-BJ-A2N8	THCA	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.A524T	DO48068	THCA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.S530F	TCGA-CV-7238	HNSC	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.7982
p.S530F	DO15246	HNSC	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.7982
p.E526K	TCGA-EE-A29E	SKCM	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	TCGA-L5-A8NN	ESCA	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	DO222868	MELA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	DO219878	SKCA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	DO229459	SKCA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	DO37831	SKCM	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	SIDM01175	Other Sarcomas	GDSC	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	ACH-002309	Sarcoma	CCLE	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.E526K	SW684	soft_tissue	COSMIC	LSTPNQS	DEG_SCF_FBW7_1	0.25
p.R523Q	TCGA-FW-A3R5	SKCM	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.1667
p.R523Q	DO37406	SKCM	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.1667
p.R540C	TCGA-GN-A269	SKCM	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.R540C	DO37483	SKCM	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.E519K	TCGA-VS-A9V3	CESC	TCGA	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.E519K	DO219743	CESC	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.E519K	DO222908	MELA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.E519K	SIDM01168	Colorectal Carcinoma	GDSC	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.E519K	SIDM00803	Kidney Carcinoma	GDSC	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.E519K	SIDM00214	Colorectal Carcinoma	GDSC	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.E519K	SIDM00720	Mesothelioma	GDSC	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.R540H	DO233158	GACA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.L543V	DO233202	GACA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.1111
p.Q534K	DO228985	LICA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.5833
p.S542F	DO222875	MELA	ICGC	LSTPNQS	DEG_SCF_FBW7_1	0.5833
p.R540L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.R540L	ACH-000924	Lung Cancer	CCLE	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.R540L	NCI-H2172	lung	COSMIC	LSTPNQS	DEG_SCF_FBW7_1	0.1944
p.E519Q	SIDM00330	Neuroblastoma	GDSC	LSTPNQS	DEG_SCF_FBW7_1	0.0556
p.E519Q	LAN-6	autonomic_ganglia	COSMIC	LSTPNQS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTPNQS

Degron related mutations and impact score

Drug responses associated with SCN9A mutations

All proteins holding degron of LSTPNQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SCF_FBW7_1	529:535	LSTPNQS	FBXW7	0.8867	More...