DegronMD

Uniprot ID: P29084

Source protein: Transcription initiation factor IIE subunit beta

Source gene: GTF2E2

Class: DEG_SCF_FBW7_2

Location: 17:23

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 86.4857

COIL: 0.7439

CONS_SCORE: 0.5242

DSS_SCORE: 0.5054

HELIX: 0.1997

FCONS_SCORE: 1.0707

RIG_SCORE: 0.7204

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L17I	TCGA-AJ-A3EL	UCEC	TCGA	LSTPVVE	DEG_SCF_FBW7_2	0.6063
p.L17I	DO41542	UCEC	ICGC	LSTPVVE	DEG_SCF_FBW7_2	0.6063
p.S31L	TCGA-BH-A0HP	BRCA	TCGA	LSTPVVE	DEG_SCF_FBW7_2	0.1111
p.S31L	DO1755	BRCA	ICGC	LSTPVVE	DEG_SCF_FBW7_2	0.1111
p.R9M	TCGA-D3-A2JN	SKCM	TCGA	LSTPVVE	DEG_SCF_FBW7_2	0.5556
p.R9M	DO47590	SKCM	ICGC	LSTPVVE	DEG_SCF_FBW7_2	0.5556
p.R15Q	TCGA-EO-A3B0	UCEC	TCGA	LSTPVVE	DEG_SCF_FBW7_2	0.2778
p.R15Q	DO219773	UCEC	ICGC	LSTPVVE	DEG_SCF_FBW7_2	0.2778
p.E8Q	DO233916	GACA	ICGC	LSTPVVE	DEG_SCF_FBW7_2	0.5278
p.R25C	SIDM01165	Pancreatic Carcinoma	GDSC	LSTPVVE	DEG_SCF_FBW7_2	0.2778
p.R25C	SIDM00039	Ovarian Carcinoma	GDSC	LSTPVVE	DEG_SCF_FBW7_2	0.2778
p.S29F	ACH-002396	Bone Cancer	CCLE	LSTPVVE	DEG_SCF_FBW7_2	0.1667
p.S29F	Sarc9371	bone	COSMIC	LSTPVVE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29084	Transcription initiation factor IIE subunit beta	DEG_SCF_FBW7_2	17:23	LSTPVVE	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons