DegronMD

Uniprot ID: Q08050

Source protein: Forkhead box protein M1

Source gene: FOXM1

Class: DEG_SCF_FBW7_1

Location: 659:666

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 58.4375

COIL: 0.8403

CONS_SCORE: 0.4059

DSS_SCORE: 0.6284

HELIX: 0.1209

FCONS_SCORE: 1.0313

RIG_SCORE: 0.6804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V670G	TCGA-77-A5GH	LUSC	TCGA	LSTTPLQS	DEG_SCF_FBW7_1	0.2222
p.V670G	DO45452	LUSC	ICGC	LSTTPLQS	DEG_SCF_FBW7_1	0.2222
p.P659L	TCGA-BH-A0HF	BRCA	TCGA	LSTTPLQS	DEG_SCF_FBW7_1	0.7582
p.P659L	DO1749	BRCA	ICGC	LSTTPLQS	DEG_SCF_FBW7_1	0.7582
p.W662C	TCGA-K4-A6MB	BLCA	TCGA	LSTTPLQS	DEG_SCF_FBW7_1	0.7
p.W662C	DO44077	BLCA	ICGC	LSTTPLQS	DEG_SCF_FBW7_1	0.7
p.G671E	DO227987	COCA	ICGC	LSTTPLQS	DEG_SCF_FBW7_1	0.1944
p.D674H	DO32904	PACA	ICGC	LSTTPLQS	DEG_SCF_FBW7_1	0.1111
p.P656L	SIDM00007	Other Solid Cancers	GDSC	LSTTPLQS	DEG_SCF_FBW7_1	0.25
p.P656L	MCC13	skin	COSMIC	LSTTPLQS	DEG_SCF_FBW7_1	0.25
p.P656S	SIDM00007	Other Solid Cancers	GDSC	LSTTPLQS	DEG_SCF_FBW7_1	0.25
p.P656S	MCC13	skin	COSMIC	LSTTPLQS	DEG_SCF_FBW7_1	0.25
p.P659T	SIDM00780	Colorectal Carcinoma	GDSC	LSTTPLQS	DEG_SCF_FBW7_1	0.7031
p.T665M	SIDM01619	Endometrial Carcinoma	GDSC	LSTTPLQS	DEG_SCF_FBW7_1	0.7423
p.P654L	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPLQS	DEG_SCF_FBW7_1	0.1944
p.P654L	TE-11	oesophagus	COSMIC	LSTTPLQS	DEG_SCF_FBW7_1	0.1944
p.P669L	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	LSTTPLQS	DEG_SCF_FBW7_1	0.25
p.P669L	TE-11	oesophagus	COSMIC	LSTTPLQS	DEG_SCF_FBW7_1	0.25
p.L659F	GMS-10	central_nervous_system	COSMIC	LSTTPLQS	DEG_SCF_FBW7_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08050	Forkhead box protein M1	DEG_SCF_FBW7_1	659:666	LSTTPLQS	FBXW7	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons