DegronMD

Uniprot ID: Q86XR8

Source protein: Centrosomal protein of 57 kDa

Source gene: CEP57

Class: DEG_SCF_FBW7_1

Location: 346:353

E3 ligase: FBXW7

DEGRON score: 0.9562

ASA_SCORE: 92.5125

COIL: 0.9394

CONS_SCORE: 0.4783

DSS_SCORE: 0.5935

HELIX: 0.0275

FCONS_SCORE: 0.9607

RIG_SCORE: 0.628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G355S	TCGA-G4-6628	COAD	TCGA	LSVTPPSS	DEG_SCF_FBW7_1	0.2778
p.E343G	DO45448	LUSC	ICGC	LSVTPPSS	DEG_SCF_FBW7_1	0.25
p.K345R	SIDM01617	Endometrial Carcinoma	GDSC	LSVTPPSS	DEG_SCF_FBW7_1	0.3056
p.D342N	ACH-001610	Brain Cancer	CCLE	LSVTPPSS	DEG_SCF_FBW7_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XR8	Centrosomal protein of 57 kDa	DEG_SCF_FBW7_1	346:353	LSVTPPSS	FBXW7	0.9562	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons