DegronMD

Uniprot ID: Q8IXT1

Source protein: DNA damage-induced apoptosis suppressor protein

Source gene: DDIAS

Class: DEG_SCF_FBW7_1

Location: 461:468

E3 ligase: FBXW7

DEGRON score: 0.5435

ASA_SCORE: 97.925

COIL: 0.8491

CONS_SCORE: 0.4991

DSS_SCORE: 0.5269

HELIX: 0.0556

FCONS_SCORE: 1.0725

RIG_SCORE: 0.6906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H455P	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LSVTPQRT	DEG_SCF_FBW7_1	0.1667
p.H455P	NCI-H810	lung	COSMIC	LSVTPQRT	DEG_SCF_FBW7_1	0.1667
p.I451T	SIDM01689	B-Lymphoblastic Leukemia	GDSC	LSVTPQRT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXT1	DNA damage-induced apoptosis suppressor protein	DEG_SCF_FBW7_1	461:468	LSVTPQRT	FBXW7	0.5435	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons