DegronMD

Uniprot ID: Q8IYE1

Source protein: Coiled-coil domain-containing protein 13

Source gene: CCDC13

Class: LIG_APCC_ABBA_1

Location: 298:303

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9881

ASA_SCORE: 90.3

COIL: 0.831

CONS_SCORE: 0.3624

DSS_SCORE: 0.554

HELIX: 0.1417

FCONS_SCORE: 1.1097

RIG_SCORE: 0.7056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S308L	TCGA-A5-A0G1	UCEC	TCGA	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	DO42472	UCEC	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM00075	Non-Cancerous	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM00242	Osteosarcoma	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM00397	Acute Myeloid Leukemia	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM00554	Ovarian Carcinoma	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM01033	Bladder Carcinoma	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM00171	Colorectal Carcinoma	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S308L	SIDM01473	Plasma Cell Myeloma	GDSC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.S290T	DO222817	BTCA	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.1111
p.A291S	DO223359	CLLE	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.1389
p.P304Q	DO233168	GACA	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.3056
p.P304Q	DO228976	LICA	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.3056
p.T293K	DO228939	LICA	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.1944
p.Q310K	DO229029	LICA	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.1389
p.P304L	DO232761	PBCA	ICGC	LSVYPD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYE1	Coiled-coil domain-containing protein 13	LIG_APCC_ABBA_1	298:303	LSVYPD	APC,CDC20,FZR1	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons