DegronMD

Uniprot ID: P23468

Source protein: Receptor-type tyrosine-protein phosphatase delta

Source gene: PTPRD

Class: DEG_SCF_FBW7_1

Location: 534:541

E3 ligase: FBXW7

DEGRON score: 0.7096

ASA_SCORE: 55.9125

COIL: 0.6006

CONS_SCORE: 0.6467

DSS_SCORE: 0.4242

HELIX: 0.0091

FCONS_SCORE: 1.0565

RIG_SCORE: 0.7419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N546K	TCGA-17-Z026	LUAD	TCGA	LSWTPPRS	DEG_SCF_FBW7_1	0.1944
p.N546K	TCGA-L5-A4OH	ESCA	TCGA	LSWTPPRS	DEG_SCF_FBW7_1	0.1944
p.A524S	TCGA-A5-A1OF	UCEC	TCGA	LSWTPPRS	DEG_SCF_FBW7_1	0.0556
p.T543I	TCGA-AP-A059	UCEC	TCGA	LSWTPPRS	DEG_SCF_FBW7_1	0.2778
p.S528Y	TCGA-AX-A2HC	UCEC	TCGA	LSWTPPRS	DEG_SCF_FBW7_1	0.1667
p.E529Q	TCGA-CV-7407	HNSC	TCGA	LSWTPPRS	DEG_SCF_FBW7_1	0.1944
p.E529Q	DO15711	HNSC	ICGC	LSWTPPRS	DEG_SCF_FBW7_1	0.1944
p.S535C	TCGA-PG-A914	UCEC	TCGA	LSWTPPRS	DEG_SCF_FBW7_1	0.643
p.S535C	DO52421	UCEC	ICGC	LSWTPPRS	DEG_SCF_FBW7_1	0.643
p.S535Y	DO233210	GACA	ICGC	LSWTPPRS	DEG_SCF_FBW7_1	0.6009
p.T527K	DO229027	LICA	ICGC	LSWTPPRS	DEG_SCF_FBW7_1	0.1389
p.S538L	DO229453	SKCA	ICGC	LSWTPPRS	DEG_SCF_FBW7_1	0.7667
p.S525Y	DO41572	UCEC	ICGC	LSWTPPRS	DEG_SCF_FBW7_1	0.0833
p.T540I	DO41361	UCEC	ICGC	LSWTPPRS	DEG_SCF_FBW7_1	0.7078
p.L534F	SIDM00238	Ovarian Carcinoma	GDSC	LSWTPPRS	DEG_SCF_FBW7_1	0.6981
p.L534F	ACH-000947	Ovarian Cancer	CCLE	LSWTPPRS	DEG_SCF_FBW7_1	0.6981
p.L534F	OVK-18	ovary	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.6981
p.S531G	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSWTPPRS	DEG_SCF_FBW7_1	0.25
p.S531G	ACH-000287	Lymphoma	CCLE	LSWTPPRS	DEG_SCF_FBW7_1	0.25
p.S531G	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.25
p.L531F	OVK-18	ovary	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.25
p.S528G	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.1667
p.R551Q	IGR-37	skin	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.0556
p.L524F	OVK-18	ovary	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.0556
p.L528F	OVK-18	ovary	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.1667
p.S525G	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LSWTPPRS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23468	Receptor-type tyrosine-protein phosphatase delta	DEG_SCF_FBW7_1	534:541	LSWTPPRS	FBXW7	0.7096	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSWTPPRS

Degron related mutations and impact score

Drug responses associated with PTPRD mutations

All proteins holding degron of LSWTPPRS