DegronMD

Uniprot ID: Q08211

Source protein: ATP-dependent RNA helicase A

Source gene: DHX9

Class: DEG_SCF_FBW7_1

Location: 91:98

E3 ligase: FBXW7

DEGRON score: 0.9909

ASA_SCORE: 78.4875

COIL: 0.8844

CONS_SCORE: 0.2711

DSS_SCORE: 0.7266

HELIX: 0.0774

FCONS_SCORE: 0.9956

RIG_SCORE: 0.6624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P95H	TCGA-B5-A11E	UCEC	TCGA	LTDTPDTT	DEG_SCF_FBW7_1	0.7694
p.P95H	TCGA-VQ-A8PP	STAD	TCGA	LTDTPDTT	DEG_SCF_FBW7_1	0.7694
p.P95H	DO51774	STAD	ICGC	LTDTPDTT	DEG_SCF_FBW7_1	0.7694
p.P95H	DO41644	UCEC	ICGC	LTDTPDTT	DEG_SCF_FBW7_1	0.7694
p.P95S	TCGA-FR-A8YC	SKCM	TCGA	LTDTPDTT	DEG_SCF_FBW7_1	0.6752
p.P95S	DO50301	SKCM	ICGC	LTDTPDTT	DEG_SCF_FBW7_1	0.6752
p.A101S	DO229028	LICA	ICGC	LTDTPDTT	DEG_SCF_FBW7_1	0.25
p.D93Y	DO229027	LICA	ICGC	LTDTPDTT	DEG_SCF_FBW7_1	0.6214
p.A99S	DO229006	LICA	ICGC	LTDTPDTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08211	ATP-dependent RNA helicase A	DEG_SCF_FBW7_1	91:98	LTDTPDTT	FBXW7	0.9909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons