DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTLFRD
Uniprot ID:
Q9UFP1
Source protein:
Golgi-associated kinase 1A
Source gene:
GASK1A
Class:
LIG_APCC_ABBA_1
Location:
567:572
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9955
ASA_SCORE:
71.95
COIL:
0.6883
CONS_SCORE:
0.7243
DSS_SCORE:
0.5977
HELIX:
0.0145
FCONS_SCORE:
1.3139
RIG_SCORE:
0.7881
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GASK1A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTLFRD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UFP1
Golgi-associated kinase 1A
LIG_APCC_ABBA_1
567:572
LTLFRD
APC,CDC20,FZR1
0.9955
More...