DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_SCF_FBW7_2

Location: 4046:4051

E3 ligase: FBXW7

DEGRON score: 0.9805

ASA_SCORE: 72.5667

COIL: 0.8458

CONS_SCORE: 0.3214

DSS_SCORE: 0.4469

HELIX: 0.0937

FCONS_SCORE: 0.9055

RIG_SCORE: 0.7131

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4044D	TCGA-19-5956	GBM	TCGA	LTPGDE	DEG_SCF_FBW7_2	0.2778
p.E4044D	DO13863	GBM	ICGC	LTPGDE	DEG_SCF_FBW7_2	0.2778
p.I4056M	TCGA-AP-A5FX	UCEC	TCGA	LTPGDE	DEG_SCF_FBW7_2	0.1944
p.I4056M	DO223082	ESCA	ICGC	LTPGDE	DEG_SCF_FBW7_2	0.1944
p.I4056M	DO49072	UCEC	ICGC	LTPGDE	DEG_SCF_FBW7_2	0.1944
p.D4050Y	DO228974	LICA	ICGC	LTPGDE	DEG_SCF_FBW7_2	0.6214
p.D4050Y	DO35406	PACA	ICGC	LTPGDE	DEG_SCF_FBW7_2	0.6214
p.A4038S	DO229036	LICA	ICGC	LTPGDE	DEG_SCF_FBW7_2	0.1111
p.G4049V	DO231141	LUSC	ICGC	LTPGDE	DEG_SCF_FBW7_2	0.6421
p.E4042V	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	LTPGDE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_SCF_FBW7_2	4046:4051	LTPGDE	FBXW7	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons