DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPGDT
Uniprot ID:
Q7Z6J2
Source protein:
Protein TAMALIN
Source gene:
TAMALIN
Class:
DEG_SCF_FBW7_1
Location:
149:154
E3 ligase:
FBXW7
DEGRON score:
0.836
ASA_SCORE:
38.3833
COIL:
0.8542
CONS_SCORE:
0.7684
DSS_SCORE:
0.361
HELIX:
0.014
FCONS_SCORE:
1.0322
RIG_SCORE:
0.7404
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D153E
SIDM00145
T-Lymphoblastic Leukemia
GDSC
LTPGDT
DEG_SCF_FBW7_1
0.5647
Drug responses associated with TAMALIN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPGDT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z6J2
Protein TAMALIN
DEG_SCF_FBW7_1
149:154
LTPGDT
FBXW7
0.836
More...