DegronMD

Uniprot ID: P02751

Source protein: Fibronectin

Source gene: FN1

Class: DEG_SCF_FBW7_2

Location: 1509:1514

E3 ligase: FBXW7

DEGRON score: 0.9504

ASA_SCORE: 54.65

COIL: 0.7627

CONS_SCORE: 0.5405

DSS_SCORE: 0.287

HELIX: 0.0065

FCONS_SCORE: 0.9483

RIG_SCORE: 0.7474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1511T	TCGA-95-A4VK	LUAD	TCGA	LTPGTE	DEG_SCF_FBW7_2	0.7031
p.P1511T	DO45360	LUAD	ICGC	LTPGTE	DEG_SCF_FBW7_2	0.7031
p.N1523Y	TCGA-EE-A3AG	SKCM	TCGA	LTPGTE	DEG_SCF_FBW7_2	0.0833
p.N1523Y	DO37471	SKCM	ICGC	LTPGTE	DEG_SCF_FBW7_2	0.0833
p.S1503F	TCGA-RD-A7BW	STAD	TCGA	LTPGTE	DEG_SCF_FBW7_2	0.1667
p.S1503F	DO48612	STAD	ICGC	LTPGTE	DEG_SCF_FBW7_2	0.1667
p.V1520I	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPGTE	DEG_SCF_FBW7_2	0.1667
p.V1520I	ACH-002272	Lymphoma	CCLE	LTPGTE	DEG_SCF_FBW7_2	0.1667
p.V1520I	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPGTE	DEG_SCF_FBW7_2	0.1667
p.L1522V	SIDM00767	Small Cell Lung Carcinoma	GDSC	LTPGTE	DEG_SCF_FBW7_2	0.1111
p.L1522V	ACH-001136	Lung Cancer	CCLE	LTPGTE	DEG_SCF_FBW7_2	0.1111
p.L1522V	NCI-H187	lung	COSMIC	LTPGTE	DEG_SCF_FBW7_2	0.1111
p.R1501Q	SIDM00783	Colorectal Carcinoma	GDSC	LTPGTE	DEG_SCF_FBW7_2	0.1111
p.R1501Q	ACH-000971	Colon/Colorectal Cancer	CCLE	LTPGTE	DEG_SCF_FBW7_2	0.1111
p.R1501Q	HCT-116	large_intestine	COSMIC	LTPGTE	DEG_SCF_FBW7_2	0.1111
p.R1524H	DIFI	large_intestine	COSMIC	LTPGTE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02751	Fibronectin	DEG_SCF_FBW7_2	1509:1514	LTPGTE	FBXW7	0.9504	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons