DegronMD

Uniprot ID: Q9H171

Source protein: Z-DNA-binding protein 1

Source gene: ZBP1

Class: DEG_SCF_FBW7_2

Location: 392:397

E3 ligase: FBXW7

DEGRON score: 0.8349

ASA_SCORE: 57.1167

COIL: 0.4015

CONS_SCORE: 0.3053

DSS_SCORE: 0.6557

HELIX: 0.5133

FCONS_SCORE: 1.0825

RIG_SCORE: 0.7108

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L396M	TCGA-22-A5C4	LUSC	TCGA	LTPKLE	DEG_SCF_FBW7_2	0.5999
p.A407V	DO232224	PBCA	ICGC	LTPKLE	DEG_SCF_FBW7_2	0.1667
p.H406P	SIDM00545	Melanoma	GDSC	LTPKLE	DEG_SCF_FBW7_2	0.0833
p.H406P	ACH-000987	Skin Cancer	CCLE	LTPKLE	DEG_SCF_FBW7_2	0.0833
p.H406P	Mewo	skin	COSMIC	LTPKLE	DEG_SCF_FBW7_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H171	Z-DNA-binding protein 1	DEG_SCF_FBW7_2	392:397	LTPKLE	FBXW7	0.8349	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons