DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPKLE
Uniprot ID:
Q9H171
Source protein:
Z-DNA-binding protein 1
Source gene:
ZBP1
Class:
DEG_SCF_FBW7_2
Location:
392:397
E3 ligase:
FBXW7
DEGRON score:
0.8349
ASA_SCORE:
57.1167
COIL:
0.4015
CONS_SCORE:
0.3053
DSS_SCORE:
0.6557
HELIX:
0.5133
FCONS_SCORE:
1.0825
RIG_SCORE:
0.7108
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L396M
TCGA-22-A5C4
LUSC
TCGA
LTPKLE
DEG_SCF_FBW7_2
0.5999
p.A407V
DO232224
PBCA
ICGC
LTPKLE
DEG_SCF_FBW7_2
0.1667
p.H406P
SIDM00545
Melanoma
GDSC
LTPKLE
DEG_SCF_FBW7_2
0.0833
p.H406P
ACH-000987
Skin Cancer
CCLE
LTPKLE
DEG_SCF_FBW7_2
0.0833
p.H406P
Mewo
skin
COSMIC
LTPKLE
DEG_SCF_FBW7_2
0.0833
Drug responses associated with ZBP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPKLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H171
Z-DNA-binding protein 1
DEG_SCF_FBW7_2
392:397
LTPKLE
FBXW7
0.8349
More...